MBX-400 (filociclovir; formerly cyclopropavir)
Oral Activity of a Methylenecyclopropane Analog, Cyclopropavir, in Animal Models for Cytomegalovirus Infections
Synthesis and Antiviral Activity of (Z)- and (E)-2,2-[Bis(hydroxymethyl)cyclopropylidene]methylpurines and pyrimidines: Second-Generation Methylenecyclopropane Analogues of Nucleosides
In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus Replication
L-Valine Ester of Cyclopropavir – a New Antiviral Prodrug
Stereoselective Phosphorylation of Cyclopropavir by pUL97 and Competitive Inhibition by Maribavir
Cyclopropravir inhibits the normal function of the human cytomegalovirus UL97 kinase
Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility
Cyclopropavir Susceptibility of Cytomegalovirus DNA Polymerase Mutants Selected after Antiviral Drug Exposure
Human Herpesvirus 6 U69 Kinase Phosphorylates the Methylenecyclopropane Nucleosides Cyclopropavir, MBX 2168, and MBX 1616 to their Monophosphates
Synthesis and Antiviral Activity of Methylenecyclopropane Analogs with 6-alkoxy and 6-alkylthio Substitutions that Exhibit Broad Spectrum Antiviral Activity against Human Herpesviruses
Cytomegalovirus mutants resistant to ganciclovir and cidofovir differ in susceptibility to synguanol and its 6-ether and 6 thioether derivatives.
Human Cytomegalovirus UL97 Kinase is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions
Cytomegalovirus UL97 Kinase Catalytic Domain Mutations that Confer Multi-Drug Resistance
Metabolism of Cyclopropavir and Ganciclovir in Human Cytomegalovirus-Infected Cells
Potency and Stereoselectivity of Cyclopropravir Triphosphate Action on Human Cytomegalovirus DNA Polymerase
TAOK3 Phosphorylates the Methylenecyclopropane Nucleoside MBX 2168 to its Monophosphate
Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides
Stereoselective approach to the Z-isomers of methylenecyclopropane analogues of nucleosdies: a new synthesis of anitviral synguanol
Spectinomycin analogs
Spectinamides are Effective Partner Agents for the Treatment of Tuberculosis in Multiple Mouse Infection Models
Aminomethyl spectinomycins as therapeutics for drug-resistant gonorrhea and chlamydial co-infections
Type III secretion system (T3SS)
Impact of Type III Secretion Effectors and of Phenoxyacetamide Inhibitors of Type III Secretion on Abscess Formation in a Mouse Model of Pseudomonas aeruginosa Infection
Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS)
Mutations in the P. aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide T3SS inhibitors of the type III secretion system
Discovery and Characterization of Inhibitors of Pseudomonas aeruginosa Type III Secretion
Efflux pump inhibitors
The hydrophobic trap: the Achilles heel of RND efflux pumps
Optimization of a novel series of pyranopyridine RND efflux pump inhibitors
Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
Recent advances toward a molecular mechanism of efflux pump inhibition
Structure-Activity Relationships of a Novel Pyranopyridine Series of Gram-negative Bacterial Efflux Pump Inhibitors
Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors
Characterization of a novel pyranopyridine inhibitor of the AcrAB efflux pump of Escherichia coli